How to Watch the San Francisco 49ers Face Trevor Lawrence and the Jacksonville Jaguars in Week 4

September 25, 2025

Week 4 of the NFL season delivers a cross-conference clash with playoff implications as the undefeated San Francisco 49ers welcome the Jacksonville Jaguars to Levi's Stadium. This matchup pits Kyle Shanahan's high-powered offense—now navigating a gauntlet of injuries—against a Jaguars squad that's found its groove defensively and on the ground. The 49ers (3-0) have scraped out gritty wins, including a 16-15 thriller over the Cardinals in Week 3 where Mac Jones stepped up in place of the sidelined Brock Purdy, while the Jaguars (2-1) notched a crucial 17-10 divisional victory over the Texans behind three takeaways and a dominant run game averaging 141.7 yards per contest. With San Francisco leading the all-time series 5-2, this could be the game where Jacksonville's opportunistic defense (league-leading nine takeaways) forces the Niners' first stumble.

Whether you're a Faithful ready to paint the Bay Area red and gold or a Jaguars fan dreaming of an upset on the road, we've compiled your go-to guide for catching every snap. From TV coverage to streaming picks and radio feeds, here's how to watch the 49ers vs. Jaguars on Sunday, September 28, 2025, at 4:05 p.m. ET (1:05 p.m. PT).

Game Details

• Teams: San Francisco 49ers (3-0) vs. Jacksonville Jaguars (2-1)
• Date: Sunday, September 28, 2025
• Time: 4:05 p.m. ET
• Location: Levi's Stadium, Santa Clara, California
• Broadcast Team: Adam Amin (play-by-play), Mark Sanchez (analyst), and Kristina Pink (sideline) on FOX – bringing energy to this West Coast showdown.

As a FOX national game, it's available across much of the U.S. in the early afternoon window. Verify local availability via the NFL TV coverage map.

How to Watch on TV

Flip to your local FOX affiliate for the live action. Pregame hype kicks off with FOX NFL Sunday at noon ET, featuring Curt Menefee, Terry Bradshaw, Howie Long, Jimmy Johnson, and Michael Strahan.

• 49ers Local Market: KTVU (Bay Area)
• Jaguars Local Market: FOX30 (Jacksonville)
• National: FOX (check listings by zip code)

Traveling? Cable providers like DirecTV, Dish, or Xfinity ensure FOX access nationwide.

Streaming Options

TV-free? Go digital with these services (subscriptions needed, with trials available):

• YouTube TV / Hulu + Live TV / FuboTV / Sling TV: All include FOX in most markets, starting at $70–$80/month with 5–7-day free trials. They pack ESPN, CBS, and NBC for full NFL slates.
• NFL+: $6.99/month (or $14.99 for Premium) streams local games on mobile. Premium adds NFL RedZone and full replays.
• NFL Sunday Ticket (YouTube TV add-on): Out-of-market viewers: $349/season for every non-local game. Promo: $299 for new subs.
• Peacock / Amazon Prime Video: Not primary here, but check for any flex scheduling.

Pro tip: Overseas? Fire up a VPN like ExpressVPN on a U.S. server to bypass geo-blocks.

Radio and Audio Broadcasts

Tailgating or commuting? Dial in:

• 49ers Radio Network:
  • Flagship: KGO (810 AM) and 107.7 The Bone (FM) in the Bay Area
  • Play-by-Play: Guy Haberman, with Tim Ryan (analyst)
  • Spanish: Jesús Zárate and Carlos Yustis on 49ers.com/esp
• Jaguars Radio Network:
  • Flagship: 1010 XL (AM) and 92.5 FM in Jacksonville
  • Play-by-Play: Frank Frangie, with Jeff Lageman
• SiriusXM NFL Radio: Channel 83 (49ers) or 228 (Jaguars). $10.99/month for streaming.
• Westwood One National: SiriusXM Channel 88 or NFL app for syndicated coverage.

Why You Can't Miss This Game

San Francisco's unbeaten streak hangs by a thread amid injuries: Nick Bosa (ACL, out for season), George Kittle, Brandon Aiyuk, and Jauan Jennings sidelined, plus Brock Purdy's status uncertain (turf toe/AC joint). Christian McCaffrey's versatility (25 receptions, 389 scrimmage yards) keeps the offense humming, but Jacksonville's D—tops in takeaways—could capitalize. Trevor Lawrence faces a familiar foe in his college rival Mac Jones (if Purdy sits), while the Jags' ground attack (5.1 ypc) tests the Niners' stout run D (3.7 ypc allowed). Odds favor the home team by 3 points (via BetMGM), but the Jags' road warrior vibe could flip it.

Current betting lines:

(Always gamble responsibly. If you or someone you know has a gambling problem, call 1-800-GAMBLER.)

Final Thoughts

Brace for a tactical chess match at Levi's—Niners' resilience vs. Jags' momentum, with McCaffrey's magic potentially stealing the show. Stream on YouTube TV or chant from the stands; this Week 4 gem could redefine both teams' trajectories. Stay locked into FanHub for injury buzz, fantasy nuggets, and more NFL breakdowns.