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How to Watch 49ers vs. Cardinals in Week 3: TV, Streaming, Kickoff Info

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Santa Clara, CA – September 18, 2025
The San Francisco 49ers (2-0) remain unbeaten after knocking off the New Orleans Saints, 26-21, in Week 2. Now, they return to Levi’s Stadium for a crucial NFC West battle against Kyler Murray and the Arizona Cardinals (1-1).
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The road doesn’t get any easier for San Francisco. Their first two games were physical slugfests, and the Cardinals enter Week 3 hungry to prove they can compete in the division after splitting their first two matchups.

Fans will recall that last season, the 49ers dominated Arizona in both meetings, including a 38-10 rout at Levi’s. Christian McCaffrey totaled over 150 yards from scrimmage in that game, while Nick Bosa and the defense recorded four sacks. But divisional games are always unpredictable — and Murray’s dual-threat ability keeps Arizona dangerous.

The question now: can Purdy, McCaffrey, and the 49ers’ defense keep their perfect start alive on Sunday?


Game Info: 49ers vs. Cardinals, Week 3

  • When: Sunday, September 21, 2025 – 4:25 p.m. ET (1:25 p.m. PT)

  • Where: Levi’s Stadium, Santa Clara, CA

  • TV: FOX

  • Streaming: NFL+, YouTube TV, Fubo

  • Radio: KNBR 680 AM / 107.7 The Bone

  • Local 49ers fans can also catch pre-game and post-game coverage on NBC Sports Bay Area.

    Sportsbooks currently list San Francisco as 6.5-point favorites heading into the matchup.

    San Francisco 49ers 2025 Schedule

    Preseason

    • Week 1: Aug. 9 vs. Broncos – L 30-9

  • Week 2: Aug. 16 @ Raiders – W 22-19

  • Week 3: Aug. 23 vs. Chargers – W 30-23

  • Regular Season

    • Week 1: Sept. 7 @ Seahawks – W 17-13

  • Week 2: Sept. 14 @ Saints – W 26-21

  • Week 3: Sept. 21 vs. Cardinals – 4:25 PM

  • Week 4: Sept. 28 vs. Jaguars – 4:05 PM

  • Week 5: Oct. 2 @ Rams – 8:15 PM (TNF)

  • Week 6: Oct. 12 @ Buccaneers – 1 PM

  • Week 7: Oct. 19 vs. Falcons – 8:20 PM (SNF)

  • Week 8: Oct. 26 @ Texans – 1 PM

  • Week 9: Nov. 2 @ Giants – 1 PM

  • Week 10: Nov. 9 vs. Rams – 4:25 PM

  • Week 11: Nov. 16 @ Cardinals – 4:05 PM

  • Week 12: Nov. 24 vs. Panthers – 8:15 PM (MNF)

  • Week 13: Nov. 30 @ Browns – 1 PM

  • Week 14: BYE

  • Week 15: Dec. 14 vs. Titans – 4:25 PM

  • Week 16: Dec. 22 @ Colts – 8:15 PM (MNF)

  • Week 17: Dec. 28 vs. Bears – 8:20 PM (SNF)

  • Week 18: Jan. 3/4 TBD vs. Seahawks

  • Steelers Linked To Saints SuperStar With 5x Pro Bowl & 2x All-Pro in Blockbuster Trade
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