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How to Watch 49ers vs. Cardinals in Week 3: TV, Streaming, Kickoff Info

Santa Clara, CA – September 18, 2025
The San Francisco 49ers (2-0) remain unbeaten after knocking off the New Orleans Saints, 26-21, in Week 2. Now, they return to Levi’s Stadium for a crucial NFC West battle against Kyler Murray and the Arizona Cardinals (1-1).



The road doesn’t get any easier for San Francisco. Their first two games were physical slugfests, and the Cardinals enter Week 3 hungry to prove they can compete in the division after splitting their first two matchups.

Fans will recall that last season, the 49ers dominated Arizona in both meetings, including a 38-10 rout at Levi’s. Christian McCaffrey totaled over 150 yards from scrimmage in that game, while Nick Bosa and the defense recorded four sacks. But divisional games are always unpredictable — and Murray’s dual-threat ability keeps Arizona dangerous.

The question now: can Purdy, McCaffrey, and the 49ers’ defense keep their perfect start alive on Sunday?


Game Info: 49ers vs. Cardinals, Week 3

  • When: Sunday, September 21, 2025 – 4:25 p.m. ET (1:25 p.m. PT)

  • Where: Levi’s Stadium, Santa Clara, CA

  • TV: FOX

  • Streaming: NFL+, YouTube TV, Fubo

  • Radio: KNBR 680 AM / 107.7 The Bone

  • Local 49ers fans can also catch pre-game and post-game coverage on NBC Sports Bay Area.

    Sportsbooks currently list San Francisco as 6.5-point favorites heading into the matchup.

    San Francisco 49ers 2025 Schedule

    Preseason

    • Week 1: Aug. 9 vs. Broncos – L 30-9

  • Week 2: Aug. 16 @ Raiders – W 22-19

  • Week 3: Aug. 23 vs. Chargers – W 30-23

  • Regular Season

    • Week 1: Sept. 7 @ Seahawks – W 17-13

  • Week 2: Sept. 14 @ Saints – W 26-21

  • Week 3: Sept. 21 vs. Cardinals – 4:25 PM

  • Week 4: Sept. 28 vs. Jaguars – 4:05 PM

  • Week 5: Oct. 2 @ Rams – 8:15 PM (TNF)

  • Week 6: Oct. 12 @ Buccaneers – 1 PM

  • Week 7: Oct. 19 vs. Falcons – 8:20 PM (SNF)

  • Week 8: Oct. 26 @ Texans – 1 PM

  • Week 9: Nov. 2 @ Giants – 1 PM

  • Week 10: Nov. 9 vs. Rams – 4:25 PM

  • Week 11: Nov. 16 @ Cardinals – 4:05 PM

  • Week 12: Nov. 24 vs. Panthers – 8:15 PM (MNF)

  • Week 13: Nov. 30 @ Browns – 1 PM

  • Week 14: BYE

  • Week 15: Dec. 14 vs. Titans – 4:25 PM

  • Week 16: Dec. 22 @ Colts – 8:15 PM (MNF)

  • Week 17: Dec. 28 vs. Bears – 8:20 PM (SNF)

  • Week 18: Jan. 3/4 TBD vs. Seahawks

  • Vikings Rookie Cut Before Season Retires to Join Military Service
    The NFL is often described as the pinnacle of athletic dreams, but for one Minnesota rookie, the path to greatness has taken a turn away from the gridiron and toward a higher calling. After signing as an undrafted free agent in May, the young cornerback fought through training camp and preseason battles, hoping to carve out a roster spot on a Vikings team searching for secondary depth and identity. That player is Zemaiah Vaughn, a standout from the University of Utah who built his name as a long, competitive boundary corner with special-teams upside. Waived in late August, Vaughn stunned teammates and fans by announcing his retirement from professional football and his decision to enlist in the U.S. military, trading a Vikings jersey for a soldier’s uniform. “I lived my NFL dream in Minnesota, but being cut before the season opened another path,” Vaughn said in a statement. “This isn’t the end — it’s a higher calling. Now, I choose to serve my country with the same heart I gave the Vikings.” At 6’3” and 187 pounds, Vaughn brought elite length for a boundary role and made his mark with poise, vision, and leadership. His preseason PFF grade of 65 reflected consistency, though the roster competition proved overwhelming. For the Vikings, the move closes the chapter on a developmental project. For Vaughn, it begins a profound new journey that echoes his reputation as a “hidden gem” — a player who always found ways to rise above. Fans in Minnesota and across the college football community saluted the decision on social media, calling it “the ultimate sacrifice” and “proof that heart is bigger than the game.” Vaughn leaves the NFL, but his next mission may prove even greater.