How to Watch 49ers vs. Cardinals in Week 3: TV, Streaming, Kickoff Info
Santa Clara, CA – September 18, 2025
The San Francisco 49ers (2-0) remain unbeaten after knocking off the New Orleans Saints, 26-21, in Week 2. Now, they return to Levi’s Stadium for a crucial NFC West battle against Kyler Murray and the Arizona Cardinals (1-1).
The road doesn’t get any easier for San Francisco. Their first two games were physical slugfests, and the Cardinals enter Week 3 hungry to prove they can compete in the division after splitting their first two matchups.
Fans will recall that last season, the 49ers dominated Arizona in both meetings, including a 38-10 rout at Levi’s. Christian McCaffrey totaled over 150 yards from scrimmage in that game, while Nick Bosa and the defense recorded four sacks. But divisional games are always unpredictable — and Murray’s dual-threat ability keeps Arizona dangerous.
The question now: can Purdy, McCaffrey, and the 49ers’ defense keep their perfect start alive on Sunday?
Game Info: 49ers vs. Cardinals, Week 3
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When: Sunday, September 21, 2025 – 4:25 p.m. ET (1:25 p.m. PT)
Where: Levi’s Stadium, Santa Clara, CA
TV: FOX
Streaming: NFL+, YouTube TV, Fubo
Radio: KNBR 680 AM / 107.7 The Bone
Local 49ers fans can also catch pre-game and post-game coverage on NBC Sports Bay Area.
Sportsbooks currently list San Francisco as 6.5-point favorites heading into the matchup.
San Francisco 49ers 2025 Schedule
Preseason
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Week 1: Aug. 9 vs. Broncos – L 30-9
Week 2: Aug. 16 @ Raiders – W 22-19
Week 3: Aug. 23 vs. Chargers – W 30-23
Regular Season
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Week 1: Sept. 7 @ Seahawks – W 17-13
Week 2: Sept. 14 @ Saints – W 26-21
Week 3: Sept. 21 vs. Cardinals – 4:25 PM
Week 4: Sept. 28 vs. Jaguars – 4:05 PM
Week 5: Oct. 2 @ Rams – 8:15 PM (TNF)
Week 6: Oct. 12 @ Buccaneers – 1 PM
Week 7: Oct. 19 vs. Falcons – 8:20 PM (SNF)
Week 8: Oct. 26 @ Texans – 1 PM
Week 9: Nov. 2 @ Giants – 1 PM
Week 10: Nov. 9 vs. Rams – 4:25 PM
Week 11: Nov. 16 @ Cardinals – 4:05 PM
Week 12: Nov. 24 vs. Panthers – 8:15 PM (MNF)
Week 13: Nov. 30 @ Browns – 1 PM
Week 14: BYE
Week 15: Dec. 14 vs. Titans – 4:25 PM
Week 16: Dec. 22 @ Colts – 8:15 PM (MNF)
Week 17: Dec. 28 vs. Bears – 8:20 PM (SNF)
Week 18: Jan. 3/4 TBD vs. Seahawks
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